Health Extended ALliance for Innovative Therapies, Advanced Lab-research, and Integrated Approaches of Precision Medicine (HEAL ITALIA)
Spoke 4 of the PNRR-funded HEAL Italia project develops innovative, predictive and minimally invasive diagnostic approaches for the early detection and monitoring of cancer and other complex diseases. By integrating molecular biomarkers, including circulating microRNAs, proteins and extracellular vesicles, with advanced imaging, clinical data and computational tools, the Spoke aims to provide a multidimensional view of disease evolution. These activities support earlier diagnosis, prognostic stratification, longitudinal monitoring and the personalization of therapeutic strategies. Discover more
Funding body: Unione Europea – NextGenerationEU.PNRR, Missione 4 “Istruzione e ricerca”, Componente 2, Investimento 1.3
Impact of Graft Reconditioning with Hypothermic Machine Perfusion on HCC Recurrence after Liver Transplantation.
The project investigates whether graft reconditioning through hypothermic machine perfusion can reduce hepatocellular carcinoma recurrence after liver transplantation. By integrating extracellular vesicle analysis, mass spectrometry-based metabolomics and lipidomics, and longitudinal liquid biopsy, the study aims to identify molecular signatures associated with recurrence and develop non-invasive tools for post-transplant monitoring. The project brings together the clinical and transplant expertise of UNIMORE with the advanced omics and chemometric capabilities of the University of Salerno, with the goal of improving organ allocation, personalizing graft perfusion strategies and supporting earlier detection of tumour relapse. Discover more
Funding body: PRIN 2022 del Ministero dell’Università e della Ricerca
BOW Project. Biomimetic extracellular vesicle-coated nanodevices.
BOW is a European research project focused on the development of biomimetic nanodevices coated with extracellular vesicle membranes. The project aims to transfer the biological targeting, circulation and organotropic properties of extracellular vesicles to magnetic nanodevices through advanced functionalization and microfluidic technologies. Biological performance and nanotoxicity are assessed in in vitro, ex vivo and in vivo models, supporting the future development of innovative diagnostic and therapeutic platforms. Discover more
Funding body: H2020-EU.1.2. – EXCELLENT SCIENCE – Future and Emerging Technologies (FET)